Mission Bay's tenant base is anchored by life sciences, biotech, healthcare technology.

Tier: prime.
Tenant character: Life-sciences and tech campus belt south of SOMA.
Average rent: $78/sqft/yr.

Mission Bay, San Francisco tenant profile

Mission Bay's tenant base is anchored by life sciences, biotech, healthcare technology.

TL;DR

Tier: prime.
Tenant character: Life-sciences and tech campus belt south of SOMA.
Average rent: $78/sqft/yr.

Who clusters here

Life sciences, biotech, healthcare technology.

What that means for newcomers

Newcomers to Mission Bay should expect peer-tenant scrutiny: covenant strength, brand fit, and signage standards are watched closely. Lease-up product underwrites by anchor tenant; secondary tenants typically benefit from anchor halo.

Key facts

city	San Francisco
submarket	Mission Bay
tier	prime
averageRentLocal	$78/sqft/yr
cityClassARentUsd	$78/sqft/yr
cityVacancyPct	31.5%

Frequently asked questions

What kind of tenants lease in Mission Bay?: Life sciences, biotech, healthcare technology.

Related

Editorial provenance

Reviewed by Miriam Hollander — Lead market analyst. Last updated 2026-04-15. See our methodology and editorial standards.

Primary sources for this page

CBRE Marketview reports — CBRE
JLL Office Insight — JLL
Cushman & Wakefield Marketbeat — Cushman & Wakefield
Savills World Research — Savills
Colliers Global Office Outlook — Colliers

Full sources index · Submit a correction

Related topics

Class A Lease Negotiation — How to negotiate a Class A office lease — the playbook from LOI to signed deal.
Hybrid Workplace Strategy — How to size, structure, and lease a Class A office for a hybrid workforce.
ESG / LEED for Tenants — How tenants evaluate, negotiate, and report on ESG performance in a Class A office lease.
Cross-border Expansion — How to run a coordinated Class A office search across multiple geographies.
Fit-out Capex — How to budget, sequence, and govern Class A office fit-out">fit-out capex.
Lease vs Flex — When premium flex (coworking, managed office) beats a conventional Class A lease — and vice versa.

Mission Bay's tenant base is anchored by life sciences, biotech, healthcare technology.

Tier: prime.
Tenant character: Life-sciences and tech campus belt south of SOMA.
Average rent: $78/sqft/yr.

Cities › San Francisco › Mission Bay › Tenant profileMission Bay, San Francisco tenant profileMission Bay's tenant base is anchored by life sciences, biotech, healthcare technology.

TL;DR

Tier: prime.
Tenant character: Life-sciences and tech campus belt south of SOMA.
Average rent: $78/sqft/yr.

Who clusters here

Life sciences, biotech, healthcare technology.

What that means for newcomers

Newcomers to Mission Bay should expect peer-tenant scrutiny: covenant strength, brand fit, and signage standards are watched closely. Lease-up product underwrites by anchor tenant; secondary tenants typically benefit from anchor halo.

Key facts

city	San Francisco
submarket	Mission Bay
tier	prime
averageRentLocal	$78/sqft/yr
cityClassARentUsd	$78/sqft/yr
cityVacancyPct	31.5%

Frequently asked questions

What kind of tenants lease in Mission Bay?: Life sciences, biotech, healthcare technology.

Related

Editorial provenance

Reviewed by Miriam Hollander — Lead market analyst. Last updated 2026-04-15. See our methodology and editorial standards.

Primary sources for this page

Full sources index · Submit a correction

Related topics

Class A Lease Negotiation — How to negotiate a Class A office lease — the playbook from LOI to signed deal.
Hybrid Workplace Strategy — How to size, structure, and lease a Class A office for a hybrid workforce.
ESG / LEED for Tenants — How tenants evaluate, negotiate, and report on ESG performance in a Class A office lease.
Cross-border Expansion — How to run a coordinated Class A office search across multiple geographies.
Fit-out Capex — How to budget, sequence, and govern Class A office fit-out">fit-out capex.
Lease vs Flex — When premium flex (coworking, managed office) beats a conventional Class A lease — and vice versa.