Mission Bay is a prime-tier San Francisco submarket with average asking rent around $78/sqft/yr.

  • Average asking rent: $78/sqft/yr.
  • Tier: prime.
  • Citywide Class A rent context: $78/sqft/yr ($78 USD).
  • Citywide vacancy: 31.5% — submarket-level availability is typically tighter at prime tier.

Mission Bay, San Francisco office rents and availability

Mission Bay is a prime-tier San Francisco submarket with average asking rent around $78/sqft/yr.

TL;DR

  • Average asking rent: $78/sqft/yr.
  • Tier: prime.
  • Citywide Class A rent context: $78/sqft/yr ($78 USD).
  • Citywide vacancy: 31.5% — submarket-level availability is typically tighter at prime tier.

Where rent sits

Mission Bay averages around $78/sqft/yr for Class A, against a citywide Class A index of 78. As a prime submarket, rent runs at or above city average with mostly tight availability.

Availability dynamics

Life-sciences and tech campus belt south of SOMA. Life sciences, biotech, healthcare technology.

Key facts

citySan Francisco
submarketMission Bay
tierprime
averageRentLocal$78/sqft/yr
cityClassARentUsd$78/sqft/yr
cityVacancyPct31.5%

Frequently asked questions

What is the average Class A rent in Mission Bay, San Francisco?
Around $78/sqft/yr. The citywide Class A index sits at $78/sqft/yr.

Related

Editorial provenance

Reviewed by Miriam Hollander — Lead market analyst. Last updated 2026-04-15. See our methodology and editorial standards.

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