Biotech and life sciences occupiers in Prague typically cluster in Karlín, plan ~320 sqft per seat at high-end fit-out ($155–220/sqft), and pay around 312 EUR/sqft ($31 USD) on Class A.
Biotech and life sciences occupiers in Prague typically cluster in Karlín, plan ~320 sqft per seat at high-end fit-out">fit-out ($155–220/sqft), and pay around 312 EUR/sqft ($31 USD) on Class A.
Biotech and life sciences occupiers in Prague typically anchor in Karlín. Tech, banking, shared services, professional services, hospitality.
Class A rent in Prague runs 312 EUR/sqft ($31 USD) on a 5-year lease with 6 months free. Prime submarkets sit at or modestly above the city index.
Typical biotech and life sciences fit-out targets high-end specification at $155–220/sqft. Branded reception, full client-facing programming, premium furniture, and specialist AV are standard.
Plan around 320 sqft per seat blended (workstation + circulation + amenity). A 100-headcount biotech office in Prague typically targets 32,000 sqft of leasable area.
Cluster effects are decisive: PhD-grade talent concentrates near academic-medical anchors and translational research institutes. Strong BPO, IT, finance back-office, and engineering talent. Charles University, Czech Technical University (ČVUT), and University of Economics (VŠE) anchor the pipeline. Multilingual (Czech, English, German, Russian) talent supports international shared-services tenancy.
Headline corporate tax: 21%. Czech double-net structure (tenant pays operating costs and property tax pass-through). 5-10 year terms standard. Rents typically quoted in EUR. Rent-free of 4-8 months on 5-year terms plus EUR 150-300/sqm TI typical.
| city | Prague |
|---|---|
| industry | Biotech and life sciences |
| naics | 541714, 541715, 325412 |
| preferredSubmarket | Karlín |
| preferredFitoutSpec | High-end |
| fitoutBand | $155–220/sqft |
| sqftPerSeat | 320 |
| classARentLocal | 312 EUR/sqft/yr |
| classARentUsd | $31/sqft/yr |
| vacancyPct | 7.6% |
| typicalLeaseYears | 5 |
| typicalRentFreeMonths | 6 |
| talentIndex | 78 |
| corporateTaxPct | 21% |
Reviewed by Class A Atlas Editorial Desk — House byline · global editorial team. Last updated 2026-04-15. See our methodology and editorial standards.